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All South America Cruises with MSC Cruises

MSC South America cruise itinerary

Here is an original and alternative way to approach South America: MSC cruises! During the winter months, there is no better way to relax than to treat yourself to a break in South America where the sun warms the summer atmosphere of the southern hemisphere.  

With itineraries from 6 to 9 nights MSC Cruises offers many possibilities to its guests: visit Buenos Aires with its atmospheres full of life and music, or stop in Rio de Janeiro to contemplate the majestic statue of Christ the Redeemer that overlooks the city.

An MSC cruise in South America combines the desire to travel and discover new horizons with the need to relax and take a few moments for a regenerating break: try the treatments at the Spa or sip a cocktail on the edge of the pool between one stop and another of your cruise!

Browse our offers for MSC cruises in South America and choose the possibility of adding Flights from Italy and airport transfers at the best price! Our agents will also be able to advise you on the best Hotel to spend a few more days in South America: ask the Taoticket experts and you will only have to think about having fun!

210 cruises
Santos Itinerary South America
from $441
price per person Taxes included
MSC Preziosa | Oct 29, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. navigation,
3. Buzios,
4. Santos
Santos Itinerary South America
from $441
price per person Taxes included
MSC Preziosa | Dec 7, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Angra Dos Reis,
3. Buzios,
4. Santos
Santos Itinerary South America
from $453
price per person Taxes included
MSC Sinfonia | Dec 5, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Santos Itinerary South America
from $453
price per person Taxes included
MSC Sinfonia | Nov 28, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Santos Itinerary South America
from $453
price per person Taxes included
MSC Sinfonia | Dec 12, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $453
price per person Taxes included
MSC Lirica | Dec 12, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $453
price per person Taxes included
MSC Lirica | Nov 28, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $453
price per person Taxes included
MSC Lirica | Dec 5, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Santos Itinerary South America
from $465
price per person Taxes included
MSC Sinfonia | Nov 25, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Ilha Grande,
3. navigation,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $484
price per person Taxes included
MSC Lirica | Dec 8, 2025
Duration: 4 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. navigation,
3. Buzios,
4. Ilha Grande,
5. Santos
Santos Itinerary South America
from $502
price per person Taxes included
MSC Preziosa | Nov 1, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. navigation,
3. Buzios,
4. Santos
Santos Itinerary South America
from $514
price per person Taxes included
MSC Preziosa | Nov 4, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. navigation,
3. Buzios,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $526
price per person Taxes included
MSC Lirica | Mar 10, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Santos Itinerary South America
from $538
price per person Taxes included
MSC Preziosa | Oct 26, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. navigation,
3. Buzios,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $538
price per person Taxes included
MSC Lirica | Mar 3, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Santos Itinerary South America
from $538
price per person Taxes included
MSC Sinfonia | Mar 3, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Santos Itinerary South America
from $538
price per person Taxes included
MSC Preziosa | Nov 7, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. navigation,
3. Buzios,
4. Santos
Santos Itinerary South America
from $550
price per person Taxes included
MSC Sinfonia | Feb 3, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Santos Itinerary South America
from $550
price per person Taxes included
MSC Sinfonia | Feb 10, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Santos Itinerary South America
from $550
price per person Taxes included
MSC Sinfonia | Feb 17, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Santos Itinerary South America
from $550
price per person Taxes included
MSC Sinfonia | Feb 24, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $550
price per person Taxes included
MSC Lirica | Feb 24, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $550
price per person Taxes included
MSC Lirica | Feb 10, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $550
price per person Taxes included
MSC Lirica | Feb 3, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Salvador Itinerary South America
Balcony from $551
price per person Taxes included
MSC Armonia | Dec 11, 2025
Duration: 3 nights
Departure from: Salvador Landing: Rio de Janeiro
Itinerary:
1. Salvador,
2. navigation,
3. Buzios,
4. Rio de Janeiro
Santos Itinerary South America
from $562
price per person Taxes included
MSC Sinfonia | Mar 10, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Santos Itinerary South America
from $568
price per person Taxes included
MSC Sinfonia | Dec 1, 2025
Duration: 4 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. navigation,
3. Buzios,
4. Ilha Grande,
5. Santos
Santos Itinerary South America
External from $568
price per person Taxes included
MSC Preziosa | Apr 2, 2026
Duration: 4 nights
Departure from: Santos Landing: Salvador
Itinerary:
1. Santos,
2. Rio de Janeiro,
3. navigation,
4. Ilheus,
5. Salvador
sold out
Brazil
Santos Itinerary South America
from $568
price per person Taxes included
MSC Lirica | Dec 1, 2025
Duration: 4 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. navigation,
3. Buzios,
4. Ilha Grande,
5. Santos
sold out
Brazil
Santos Itinerary South America
Balcony from $617
price per person Taxes included
MSC Seaview | Apr 11, 2026
Duration: 4 nights
Departure from: Santos Landing: Maceio
Itinerary:
1. Santos,
2. Rio de Janeiro,
3. navigation,
4. navigation,
5. Maceio
210 cruises