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All South America Cruises with MSC Cruises

MSC South America cruise itinerary

Here is an original and alternative way to approach South America: MSC cruises! During the winter months, there is no better way to relax than to treat yourself to a break in South America where the sun warms the summer atmosphere of the southern hemisphere.  

With itineraries from 6 to 9 nights MSC Cruises offers many possibilities to its guests: visit Buenos Aires with its atmospheres full of life and music, or stop in Rio de Janeiro to contemplate the majestic statue of Christ the Redeemer that overlooks the city.

An MSC cruise in South America combines the desire to travel and discover new horizons with the need to relax and take a few moments for a regenerating break: try the treatments at the Spa or sip a cocktail on the edge of the pool between one stop and another of your cruise!

Browse our offers for MSC cruises in South America and choose the possibility of adding Flights from Italy and airport transfers at the best price! Our agents will also be able to advise you on the best Hotel to spend a few more days in South America: ask the Taoticket experts and you will only have to think about having fun!

210 cruises
Santos Itinerary South America
from $441
price per person Taxes included
MSC Preziosa | Dec 7, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Angra Dos Reis,
3. Buzios,
4. Santos
Santos Itinerary South America
from $441
price per person Taxes included
MSC Preziosa | Oct 29, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. navigation,
3. Buzios,
4. Santos
Santos Itinerary South America
from $453
price per person Taxes included
MSC Sinfonia | Dec 5, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Santos Itinerary South America
from $453
price per person Taxes included
MSC Sinfonia | Nov 28, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $453
price per person Taxes included
MSC Lirica | Nov 28, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $453
price per person Taxes included
MSC Lirica | Dec 12, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $453
price per person Taxes included
MSC Lirica | Dec 5, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Santos Itinerary South America
from $453
price per person Taxes included
MSC Sinfonia | Dec 12, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Santos Itinerary South America
from $478
price per person Taxes included
MSC Sinfonia | Nov 25, 2025
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Ilha Grande,
3. navigation,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $484
price per person Taxes included
MSC Lirica | Dec 8, 2025
Duration: 4 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. navigation,
3. Buzios,
4. Ilha Grande,
5. Santos
210 cruises