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All South America Cruises with MSC Cruises

  • 2027
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MSC South America cruise itinerary

Here is an original and alternative way to approach South America: MSC cruises! During the winter months, there is no better way to relax than to treat yourself to a break in South America where the sun warms the summer atmosphere of the southern hemisphere.  

With itineraries from 6 to 9 nights MSC Cruises offers many possibilities to its guests: visit Buenos Aires with its atmospheres full of life and music, or stop in Rio de Janeiro to contemplate the majestic statue of Christ the Redeemer that overlooks the city.

An MSC cruise in South America combines the desire to travel and discover new horizons with the need to relax and take a few moments for a regenerating break: try the treatments at the Spa or sip a cocktail on the edge of the pool between one stop and another of your cruise!

Browse our offers for MSC cruises in South America and choose the possibility of adding Flights from Italy and airport transfers at the best price! Our agents will also be able to advise you on the best Hotel to spend a few more days in South America: ask the Taoticket experts and you will only have to think about having fun!

272 cruises
Santos Itinerary South America
from $284
price per person Taxes included
MSC Musica | Jan 14, 2027
Duration: 3 nights
Departure from: Santos Landing: Itajai
Itinerary:
1. Santos,
2. Camboriú,
3. Paranagua,
4. Itajai
sold out
Brazil
Santos Itinerary South America
from $368
price per person Taxes included
MSC Lirica | Dec 6, 2026
Duration: 3 nights
Departure from: Santos Landing: Rio de Janeiro
Itinerary:
1. Santos,
2. Itajai,
3. Ilhabela,
4. Rio de Janeiro
Salvador Itinerary South America
from $457
price per person Taxes included
MSC Divina | Nov 12, 2026
Duration: 4 nights
Departure from: Salvador Landing: Santos
Itinerary:
1. Salvador,
2. navigation,
3. navigation,
4. Rio de Janeiro,
5. Santos
sold out
Brazil
Santos Itinerary South America
from $502
price per person Taxes included
MSC Musica | Feb 9, 2027
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. navigation,
3. Buzios,
4. Santos
Santos Itinerary South America
from $502
price per person Taxes included
MSC Musica | Nov 30, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Salvador Itinerary South America
from $518
price per person Taxes included
MSC Virtuosa | Nov 28, 2026
Duration: 4 nights
Departure from: Salvador Landing: Santos
Itinerary:
1. Salvador,
2. navigation,
3. navigation,
4. Rio de Janeiro,
5. Santos
sold out
Brazil
Santos Itinerary South America
from $526
price per person Taxes included
MSC Lirica | Mar 10, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
Santos Itinerary South America
from $526
price per person Taxes included
MSC Musica | Dec 3, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $538
price per person Taxes included
MSC Lirica | Mar 3, 2026
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
sold out
Brazil
Santos Itinerary South America
from $538
price per person Taxes included
MSC Musica | Feb 26, 2027
Duration: 3 nights
Departure from: Santos Landing: Santos
Itinerary:
1. Santos,
2. Buzios,
3. navigation,
4. Santos
272 cruises