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Departure calendar Panama City

Browse the catalog of all cruises departing from Panama City now and find the one that suits your needs best.

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December 2024

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Cruises from Panama City

Panama City, the capital of Panama, is a vibrant, cosmopolitan metropolis where a rich history meets a dynamic modern culture. The city is a mix of old and new, historic districts perfectly coexist with modern infrastructure. On the one hand, visitors have the opportunity to visit many historical attractions. The best way to learn about the canal's history and operations is to visit the Miraflores Locks or, if you want to learn more about the history of the city, you should visit the districts of Casco Viejo or Panama Viejo.

Caribbean: Panama, Costa Rica, Jamaica, Cayman Islands, Mexico, Bahamas, United States

from R 15 493,12
price per person Taxes included

See the cruise Book

Norwegian Gem | 11 Dec 2024

Duration: 9 nights

Departure from: Panama City Landing: Miami

Itinerary:

1. Panama City,

2. navigation,

3. Limón,

4. navigation,

5. Falmouth,

6. George Town,

7. Cozumel Island,

8. navigation,

9. Stirrup Cay,

10. Miami

Caribbean: Panama, Colombia, Jamaica, Cayman Islands, Honduras, Belize, Mexico, United States

from R 23 168,43
price per person Taxes included

3 reservations in 72 hours

See the cruise Book

Norwegian Jade | 19 Jan 2025

Duration: 10 nights

Departure from: Panama City Landing: Tampa

Itinerary:

1. Panama City,

2. navigation,

3. Cartagena De Indias,

4. navigation,

5. Falmouth,

6. George Town,

7. Roatan,

8. Harvest Cay,

9. Cozumel Island,

10. navigation,

11. Tampa

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles, Saint Kitts and Nevis, British Virgin Islands, Dominican Republic, United States

from R 27 423,44
price per person Taxes included

3 reservations in 48 hours

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Norwegian Jade | 09 Feb 2025

Duration: 11 nights

Departure from: Panama City Landing: Miami

Itinerary:

1. Panama City,

2. navigation,

3. Cartagena De Indias,

4. navigation,

5. Oranjestad,

6. Willemstad,

7. navigation,

8. Basseterre,

9. Tortola Island,

10. San Felipe de Puerto Plata,

11. navigation,

12. Miami

Caribbean: Panama, Spain, Colombia, Aruba, Netherlands Antilles, Jamaica, Bahamas, United States

from R 56 780,97
price per person Taxes included

10 reservations in 36 hours

See the cruise Book

Sirena | 18 Feb 2025

Duration: 11 nights

Departure from: Panama City Landing: Miami

Itinerary:

1. Panama City,

2. navigation,

3. Panama City,

4. Cartagena ,

5. Santa Marta,

6. Oranjestad,

7. Willemstad,

8. Kralendijk,

9. navigation,

10. Port Antonio,

11. navigation,

12. Nassau,

13. Miami

Panama, Colombia, Jamaica, Cayman Islands, Mexico, Bahamas, United States

from R 20 155,31
price per person Taxes included

Norwegian Jade | 04 Mar 2025

Duration: 9 nights

Departure from: Panama City Landing: Port Canaveral

Itinerary:

1. Panama City,

2. navigation,

3. Cartagena De Indias,

4. navigation,

5. Ocho Rios,

6. George Town,

7. Cozumel Island,

8. navigation,

9. Stirrup Cay,

10. Port Canaveral

Panama, Costa Rica, Aruba, Netherlands Antilles, Jamaica, Cayman Islands, United States

from R 23 046,27
price per person Taxes included

Norwegian Jade | 24 Mar 2025

Duration: 10 nights

Departure from: Panama City Landing: Tampa

Itinerary:

1. Panama City,

2. navigation,

3. Limón,

4. navigation,

5. Oranjestad,

6. Willemstad,

7. navigation,

8. Ocho Rios,

9. George Town,

10. navigation,

11. Tampa

Caribbean: Panama, Spain, Colombia, Aruba, Netherlands Antilles, Jamaica, United States

from R 53 116,37
price per person Taxes included

10 reservations in 48 hours

See the cruise Book

Sirena | 02 Apr 2025

Duration: 10 nights

Departure from: Panama City Landing: Miami

Itinerary:

1. Panama City,

2. navigation,

3. Panama City,

4. Cartagena ,

5. Santa Marta,

6. Oranjestad,

7. Willemstad,

8. Kralendijk,

9. navigation,

10. Port Antonio,

11. navigation,

12. Miami

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

from R 16 490,71
price per person Taxes included

3 reservations in 48 hours

See the cruise Book

Serenade Of The Seas | 11 Oct 2025

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. Willemstad,

5. Oranjestad,

6. navigation,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

from R 17 895,47
price per person Taxes included

3 reservations in 72 hours

See the cruise Book

Serenade Of The Seas | 18 Oct 2025

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. Oranjestad,

5. Willemstad,

6. navigation,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

from R 15 900,30
price per person Taxes included

2 reservations in 72 hours

See the cruise Book

Serenade Of The Seas | 25 Oct 2025

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. Willemstad,

5. Oranjestad,

6. navigation,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

from R 15 900,30
price per person Taxes included

3 reservations in 48 hours

See the cruise Book

Serenade Of The Seas | 01 Nov 2025

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. Oranjestad,

5. Willemstad,

6. navigation,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Netherlands Antilles

from R 14 047,64
price per person Taxes included

4 reservations in 72 hours

See the cruise Book

Serenade Of The Seas | 08 Nov 2025

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. Kralendijk,

5. Willemstad,

6. navigation,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Jamaica, Cayman Islands, Honduras, Belize, Mexico, United States

from R 28 767,13
price per person Taxes included

5 reservations in 48 hours

See the cruise Book

Norwegian Jade | 10 Nov 2025

Duration: 10 nights

Departure from: Panama City Landing: Miami

Itinerary:

1. Panama City,

2. navigation,

3. Cartagena De Indias,

4. navigation,

5. Ocho Rios,

6. George Town,

7. Roatan,

8. Harvest Cay,

9. Cozumel Island,

10. navigation,

11. Miami

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

from R 15 411,69
price per person Taxes included

5 reservations in 48 hours

See the cruise Book

Serenade Of The Seas | 15 Nov 2025

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. Oranjestad,

5. Willemstad,

6. navigation,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

from R 17 101,48
price per person Taxes included

4 reservations in 72 hours

See the cruise Book

Serenade Of The Seas | 22 Nov 2025

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. navigation,

5. Oranjestad,

6. Willemstad,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Netherlands Antilles

from R 17 142,19
price per person Taxes included

2 reservations in 72 hours

See the cruise Book

Serenade Of The Seas | 29 Nov 2025

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. Kralendijk,

5. Willemstad,

6. navigation,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

from R 16 042,81
price per person Taxes included

4 reservations in 48 hours

See the cruise Book

Serenade Of The Seas | 06 Dec 2025

Duration: 6 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. Oranjestad,

5. Willemstad,

6. navigation,

7. Panama City

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

from R 18 872,70
price per person Taxes included

2 reservations in 72 hours

See the cruise Book

Serenade Of The Seas | 12 Dec 2025

Duration: 8 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. navigation,

3. Cartagena De Indias,

4. navigation,

5. Kralendijk,

6. Oranjestad,

7. Willemstad,

8. navigation,

9. Panama City

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

from R 21 539,72
price per person Taxes included

See the cruise Book

Serenade Of The Seas | 20 Dec 2025

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. navigation,

5. Kralendijk,

6. Oranjestad,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles, Saint Lucia, Saint Kitts and Nevis, British Virgin Islands, Dominican Republic, United States

from R 44 524,91
price per person Taxes included

5 reservations in 48 hours

See the cruise Book

Norwegian Jade | 22 Dec 2025

Duration: 13 nights

Departure from: Panama City Landing: New York

Itinerary:

1. Panama City,

2. navigation,

3. Cartagena De Indias,

4. navigation,

5. Oranjestad,

6. Willemstad,

7. navigation,

8. Castries,

9. Basseterre,

10. Tortola Island,

11. San Felipe de Puerto Plata,

12. navigation,

13. navigation,

14. New York

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

from R 22 394,79
price per person Taxes included

5 reservations in 48 hours

See the cruise Book

Serenade Of The Seas | 27 Dec 2025

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. Oranjestad,

5. Kralendijk,

6. navigation,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

from R 16 429,63
price per person Taxes included

3 reservations in 48 hours

See the cruise Book

Serenade Of The Seas | 03 Jan 2026

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. navigation,

5. Kralendijk,

6. Oranjestad,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

from R 16 226,04
price per person Taxes included

See the cruise Book

Serenade Of The Seas | 10 Jan 2026

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. Oranjestad,

5. navigation,

6. Willemstad,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Netherlands Antilles, Aruba

from R 13 864,41
price per person Taxes included

5 reservations in 72 hours

See the cruise Book

Serenade Of The Seas | 17 Jan 2026

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. Kralendijk,

5. Oranjestad,

6. navigation,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

from R 13 864,41
price per person Taxes included

4 reservations in 48 hours

See the cruise Book

Serenade Of The Seas | 24 Jan 2026

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. Oranjestad,

5. Kralendijk,

6. navigation,

7. navigation,

8. Panama City

Central America: Panama, Colombia, Jamaica, Cayman Islands, Honduras, Belize, Mexico, United States

from R 30 131,17
price per person Taxes included

4 reservations in 72 hours

See the cruise Book

Norwegian Jade | 26 Jan 2026

Duration: 11 nights

Departure from: Panama City Landing: Galveston

Itinerary:

1. Panama City,

2. navigation,

3. Cartagena De Indias,

4. navigation,

5. Ocho Rios,

6. George Town,

7. Roatan,

8. Harvest Cay,

9. Costa Maya,

10. Cozumel Island,

11. navigation,

12. Galveston

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

from R 13 294,36
price per person Taxes included

2 reservations in 48 hours

See the cruise Book

Serenade Of The Seas | 31 Jan 2026

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. Oranjestad,

5. Kralendijk,

6. navigation,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

from R 13 599,75
price per person Taxes included

See the cruise Book

Serenade Of The Seas | 07 Feb 2026

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. Oranjestad,

5. Kralendijk,

6. navigation,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Aruba, Netherlands Antilles

from R 14 393,74
price per person Taxes included

2 reservations in 72 hours

See the cruise Book

Serenade Of The Seas | 14 Feb 2026

Duration: 7 nights

Departure from: Panama City Landing: Panama City

Itinerary:

1. Panama City,

2. Cartagena De Indias,

3. navigation,

4. navigation,

5. Oranjestad,

6. Willemstad,

7. navigation,

8. Panama City

Caribbean: Panama, Colombia, Aruba, Saint Lucia, Saint Kitts and Nevis, British Virgin Islands, Dominican Republic, United States

from R 29 703,64
price per person Taxes included

See the cruise Book

Norwegian Jade | 16 Feb 2026

Duration: 11 nights

Departure from: Panama City Landing: Miami

Itinerary:

1. Panama City,

2. navigation,

3. Cartagena De Indias,

4. navigation,

5. Oranjestad,

6. navigation,

7. Castries,

8. Basseterre,

9. Tortola Island,

10. San Felipe de Puerto Plata,

11. navigation,

12. Miami

In Casco Viejo, a UNESCO World Heritage Site, you can see examples of colonial architecture, a vibrant nightlife, and cultural landmarks such as the Panama Cathedral and the Presidential Palace while Panama Viejo offers the opportunity to visit the ruins of the original city and it provides a glimpse into the early history of Panama. On the other hand, Panama City is currently known for its impressive skyline that reflect its status as a financial center. The modern culture of the city is mainly visible in the banking area and along one the city’s main streets, Calle 50, where large, shiny glass buildings line the streets.