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Cruises from Panama City

Panama City, the capital of Panama, is a vibrant and cosmopolitan metropolis, where a rich history meets a dynamic modern culture. The city is a mix of old and new, the historic districts live in perfect harmony with modern infrastructure. On the one hand, visitors have the opportunity to visit many historical attractions. The best way to learn about the history and operations of the canal is to visit the Miraflores locks or, if you want to deepen your knowledge related to the history of the city, visiting the Casco Viejo or Panama Viejo neighborhoods is the best choice.

In Casco Viejo, a UNESCO World Heritage Site,you can admire examples of colonial architecture, a lively nightlife and cultural landmarks such as the Panama Cathedral and the Presidential Palace, while Panama Viejo offers the opportunity to visit the ruins of the original city and provides a glimpse into the early history of Panama.

3 cruises
Panama City Itinerary Central America
Suite from $7,460
price per person Taxes included
Explora III | Apr 22, 2027
Duration: 11 nights
Departure from: Panama City Landing: Los Angeles
Itinerary:
1. Panama City,
2. navigation,
3. navigation,
4. Acajutla,
5. Puerto Quetzal,
6. Ciudad Madero,
7. Huatulco,
8. navigation,
9. Puerto Vallarta,
10. navigation,
11. navigation,
12. Los Angeles
Panama City Itinerary Central America
Suite from $7,745
price per person Taxes included
Hanseatic Inspiration | Nov 8, 2025
Duration: 11 nights
Departure from: Panama City Landing: Colon
Itinerary:
1. Panama City,
3. Quepos,
4. Playa Panama,
6. Puntarenas,
8. San Miguelito,
9. San Miguelito,
10. Panama Canal,
11. Colon,
12. Colon
Panama City Itinerary Central America
Suite from $8,472
price per person Taxes included
Hanseatic Inspiration | Nov 8, 2025
Duration: 10 nights
Departure from: Panama City Landing: Colon
Itinerary:
1. Panama City,
3. Quepos,
4. navigation,
5. Puntarenas,
7. Playa Panama,
8. Panama Canal,
10. Colon,
11. Colon
3 cruises

Departure calendar Panama City

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On the other hand, Panama City is currently known for its impressive skyline that reflects its status as a financial center. The modern culture of the city is especially visible in the banking area and along one of the city's main streets, Calle 50, where large shiny glass buildings follow one another.

All ships departing from Panama City

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